化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl chloroformate → Ethyl 3-methyl-4-oxopiperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 1-Benzyl-3-methyl-4-piperidone | HCID 560965 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Ethyl 3-methyl-4-oxopiperidine-1-carboxylate | HCID 15075657 | — |
反応手順
Ethyl chloroformate (3.0 g, 26.7 mmol) was added to a stirred solution of 1-benzyl-3-methyl-4-piperidinone (2.0 g, 9.85 mmol) in benzene (30 ml) at ambient temperature. The obtained reaction mixture was refluxed with stirring for 6 hr and concentrated to dryness to give 1-carbethoxy-3-methyl-4-piperidone as oil. Yield 1.4 g (77%), C9H15NO3, m/z 186 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07393957B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-bfe13196bddf4f0f97ac0ec455d56a67 |
| 出典メモ | uspto-grants-2008_07 |