関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromo-2-fluoroaniline | HCID 123050 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 10707048 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 21991041 | — |
反応手順
A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.2 g, 0.74 mmol), (prepared as described for the starting material in Example 2), and 4-bromo-2-fluoroaniline (155 mg, 0.82 mmol) in DMF (2.5 ml) was heated at 150° C. for 45 minutes. After cooling to ambient temperature the mixture was treated as described in Example 3 to give 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (150 mg, 44%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087602B2 |
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| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-4999a6c79aa54fdc9a81de8483259748 |
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| 出典メモ | uspto-grants-2006_08 |
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