4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine → (1H-Benzoimidazol-4-yl)-[6-(4-trifluoromethylphenyl)pyrimidin-4-yl]amine

HRID 747125

反応式

HRID 747125 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[CH:4][N:3]=1.[NH2:18][C:19]1[C:27]2[NH:26][CH:25]=[N:24][C:23]=2[CH:22]=[CH:21][CH:20]=1>>[NH:24]1[C:23]2[CH:22]=[CH:21][CH:20]=[C:19]([NH:18][C:2]3[CH:7]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=4)[N:5]=[CH:4][N:3]=3)[C:27]=2[N:26]=[CH:25]1

参加物

3

反応物 2

HCID 167478374-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineHCID 178507452HCID 178507452、化合物

生成物 1

HCID 9820006(1H-Benzoimidazol-4-yl)-[6-(4-trifluoromethylphenyl)pyrimidin-4-yl]amine

実験手順

Analogous to the procedure used to prepare Example 5(b), 4-chloro-6-(4-trifluoromethylphenyl)pyrimidine, Example 5(a), (690 mg, 2.67 mmol) and 4-aminobenzimidazole (296 mg, 2.22 mmol, Astatech) afforded after purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2, the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 356 (M+1).

後処理

  1. customafforded
  2. customafter purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2

出典と根拠

ORDレコード
ord-220449cfc8e345079efc7a979eb775dc
出典データセット
uspto-grants-2008_07
特許番号
US07396831B2

関連ノート

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