Propylamine → 4,6-Di(2-furyl)-5-[2-(propylamino)-4-pyridyl]-2-pyrimidinamine

HRID 747165ノート

反応式

HRID 747165 の反応式
F[C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[O:21][CH:22]=[CH:23][CH:24]=3)=[N:10][C:11]([NH2:19])=[N:12][C:13]=2[C:14]2[O:15][CH:16]=[CH:17][CH:18]=2)[CH:5]=[CH:4][N:3]=1.[CH2:25]([NH2:28])[CH2:26][CH3:27]>>[O:21]1[CH:22]=[CH:23][CH:24]=[C:20]1[C:9]1[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:28][CH2:25][CH2:26][CH3:27])[CH:7]=2)=[C:13]([C:14]2[O:15][CH:16]=[CH:17][CH:18]=2)[N:12]=[C:11]([NH2:19])[N:10]=1

参加物

3

反応物 2

HCID 7852PropylamineHCID 23020419HCID 23020419、化合物

生成物 1

HCID 597490934,6-Di(2-furyl)-5-[2-(propylamino)-4-pyridyl]-2-pyrimidinamine収率 64%

反応条件

温度
120 °C

実験手順

In a reaction vessel, 5-(2-fluoro-4-pyridyl)-4,6-di(2-furyl)-2-pyrimidinamine (200 mg, 0.621 mmol) and n-propylamine (5 ml) were mixed together and the mixture was stirred at 120° C. After 18 hours, the reaction mixture was extracted with ethyl acetate, and the extract was washed with water and brine, dried over anhydrous sodium sulfate and then the filtrate was concentrated. The resulting solid was suspended in ethanol, collected by filtration and washed with ethanol, to give the title compound (64%,72 mg) as a pale yellow solid.

後処理

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washthe extract was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationthe filtrate was concentrated
  5. filtrationcollected by filtration
  6. washwashed with ethanol

出典と根拠

ORDレコード
ord-cb2fec0bde784a8fb04f504fae7bee61
出典データセット
uspto-grants-2008_07
特許番号
US07396836B2

反応ノート

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