5-Azidomethyl-3-(5-bromo-pyridin-2-yl)-4,5-dihydro-isoxazole → N-[3-(5-Bromo-pyridin-2-yl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide
反応式
[N:1]([CH2:4][CH:5]1[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][N:11]=2)[CH2:6]1)=[N+]=[N-].[C:17]([OH:20])(=S)[CH3:18]>>[Br:16][C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH2:6][CH:5]([CH2:4][NH:1][C:17](=[O:20])[CH3:18])[O:9][N:8]=2)=[N:11][CH:12]=1参加物
3
実験手順
5-Azidomethyl-3-(5-bromo-pyridin-2-yl)-4,5-dihydro-isoxazole (3 g, 10.6 mmol) and thioacetic acid (10 ml) were combined and stirred for 52 hours. The reaction mixture was concentrated in vacuo and then ethyl acetate (20 ml) was added. The resulting precipitate was filtered and washed with ethyl acetate (2×20 ml) to give the desired product (1.8 g).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- additionethyl acetate (20 ml) was added
- filtrationThe resulting precipitate was filtered
- washwashed with ethyl acetate (2×20 ml)
出典と根拠
- ORDレコード
- ord-7cbdd22013e542f3a185b3fa8aec6a5e
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396847B2
反応ノート
読み込み中…