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Formamide → 5-(3-Methoxyphenyl)-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formamide | HCID 713 | — |
| 反応物 | Bromomethyl 3-methoxyphenyl ketone | HCID 101294 | — |
| 反応物 | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| 生成物 | 5-(3-Methoxyphenyl)-1H-imidazole | HCID 22018649 | 43% |
反応手順
Reaction of 2-bromo-1-(3-methoxy-phenyl)-ethanone (2.5 g, 10.90 mmol), and formamide (3.1 mL, 76.40 mmol), followed by chromatography (CH2Cl2/MeOH/NH4OH 48:1:1) gave the title compound (820 mg, 43%) as a white solid. 1H NMR (300 MHz, CD3OD) δ 3.83 (s, 3H), 6.78-6.82 (m, 1H), 7.26-7.28 (m, 3H), 7.42 (s, 1H), 7.72 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07396840B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-4af4aa12214d4224add3015d15b440bb |
| 出典メモ | uspto-grants-2008_07 |