N-benzimidazolyl-1,2-propanediol → (1H-Benzimidazol-1-yl)acetaldehyde

HRID 747325

反応式

HRID 747325 の反応式
[N:1]1([CH:10](O)[CH:11]([OH:13])C)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.I([O-])(=O)(=O)=O.[Na+]>O>[N:1]1([CH2:10][CH:11]=[O:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

4

反応物 2

HCID 22018573N-benzimidazolyl-1,2-propanediolHCID 23667635Sodium periodate

生成物 1

HCID 22018662(1H-Benzimidazol-1-yl)acetaldehyde収率 41.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The intermediate, N-benzimidazolyl-1,2-propanediol (0.66 g, 3.4 mmol) from above was dissolved in water (25 mL) and treated with sodium periodate (0.88 g, 4.1 mmol) with stirring for 1.5 hours. The solution was then extracted with dichloromethane, dried (MgSO4), filtered and concentrated to yield 2-(benzimidazol-1-yl)-ethanal (0.22 g, 1.4 mmol) which was used immediately without further purification in the next reaction.

後処理

  1. extractionThe solution was then extracted with dichloromethane
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-07e02f8835a44c29a64f8bdb57c39cac
出典データセット
uspto-grants-2008_07
特許番号
US07396840B2

関連ノート

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