Hydrochloric Acid → HCID 22351003、化合物

HRID 747503ノート

反応式

HRID 747503 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH2:21][CH2:22][CH2:23][NH:24]C(=O)OC(C)(C)C)[C:11](=[N:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[S:12][CH:13]=2)=[CH:5][CH:4]=1.Cl>O1CCOCC1>[NH2:24][CH2:23][CH2:22][CH2:21][N:10]1[C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:13][S:12][C:11]1=[N:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22351001t-butyl 3-[4-(4-methoxyphenyl)-2-(phenylimino)thiazol-3(2H)-yl]propylcarbamate

生成物 1

HCID 22351003HCID 22351003、化合物収率 122.7%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of t-butyl 3-[4-(4-methoxyphenyl)-2-(phenylimino)-thiazol-3(2H)-yl]propylcarbamate (400 mg) and a 4N solution of hydrogen chloride in dioxane (8 ml) was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and to the residue was added diethyl ether. The insoluble salt was collected by filtration to give the title compound (379 mg) as hydrochloride.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. additionto the residue was added diethyl ether
  3. filtrationThe insoluble salt was collected by filtration

出典と根拠

ORDレコード
ord-692a4af97287428bb06cfaada5974a65
出典データセット
uspto-grants-2008_07
特許番号
US07396842B2

反応ノート

読み込み中…