Hydrochloric Acid → (2-Amino-5-fluorophenyl)-(2-chlorophenyl)methanol

HRID 747604ノート

反応式

HRID 747604 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])=[O:12])([O-])=O.[Sn].Cl>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])[OH:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 68569266(2-Nitro-5-fluorophenyl)(2-chlorophenyl)methanone

生成物 1

HCID 68567746(2-Amino-5-fluorophenyl)-(2-chlorophenyl)methanol収率 100.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 0.5 g of (2-nitro-5-fluorophenyl)(2-chlorophenyl)methanone dissolved in 10 ml of ethanol are added 0.44 g of tin and 1.5 ml of 12M hydrochloric acid, and the mixture is left for 3 hours at room temperature. The reaction medium is concentrated and the residue is taken up in ethyl acetate and washed with 2M sodium hydroxide solution and then with saturated ammonium chloride solution. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 0.453 g of the expected product.

後処理

  1. concentrationThe reaction medium is concentrated
  2. washwashed with 2M sodium hydroxide solution
  3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a38e9f99595b444aaffe62b79dc614b5
出典データセット
uspto-grants-2008_07
特許番号
US07396958B2

反応ノート

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