Ammonia → N-[2-(3-cyanophenoxy)ethyl]-4-carbamoylbenzamide

HRID 747663ノート

反応式

HRID 747663 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][CH:24]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16](OC)=[O:17])=[CH:14][CH:13]=1)=[O:11])#[N:2].[NH3:25]>>[C:1]([C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][CH:24]=1)[O:6][CH2:7][CH2:8][NH:9][C:10](=[O:11])[C:12]1[CH:21]=[CH:20][C:15]([C:16](=[O:17])[NH2:25])=[CH:14][CH:13]=1)#[N:2]

参加物

3

反応物 2

HCID 222AmmoniaHCID 68830761methyl 4-[N-[2-(3-cyanophenoxy)ethyl)carbamoyl]benzoate

生成物 1

HCID 68835528N-[2-(3-cyanophenoxy)ethyl]-4-carbamoylbenzamide

実験手順

100 mg (0.31 mmol) of methyl 4-[N-[2-(3-cyanophenoxy)ethyl)carbamoyl]benzoate was stirred in 100 ml of 28% aqueous ammonia overnight. The reaction liquid was evaporated under reduced pressure, and 1 N hydrochloric acid was added to the residue. After the extraction with ethyl acetate, the organic layer was washed with saturated aqueous NaCl solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

後処理

  1. customThe reaction liquid
  2. customwas evaporated under reduced pressure, and 1 N hydrochloric acid
  3. additionwas added to the residue
  4. extractionAfter the extraction with ethyl acetate
  5. washthe organic layer was washed with saturated aqueous NaCl solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-8fb0f1d5eebf44a795ebaed067c60749
出典データセット
uspto-grants-2008_07
特許番号
US07396844B1

反応ノート

読み込み中…