Ethylenediamine → ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

HRID 747667

反応式

HRID 747667 の反応式
Cl.C(O[C:5]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1)=[NH:6])C.[CH2:18](N)[CH2:19][NH2:20]>C(O)C>[NH:20]1[CH2:19][CH2:18][N:6]=[C:5]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][CH:17]=1

参加物

4

反応物 2

HCID 3301EthylenediamineHCID 68830640Ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride

生成物 1

HCID 22709787ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.96 g (11.5 mmol) of ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride and 690 mg (11.5 mmol) of ethylenediamine were stirred in 100 ml of ethanol at 60° C. for 4 hours. The solvent was evaporated. 1 N aqueous sodium hydroxide solution was added to the residue. After the extraction with dichloromethane followed by the washing with saturated Aqueous NaCl solution and drying over anhydrous magnesium sulfate, the solvent was evaporated to obtain the title compound.

後処理

  1. customThe solvent was evaporated
  2. addition1 N aqueous sodium hydroxide solution was added to the residue
  3. extractionAfter the extraction with dichloromethane
  4. dry with materialdrying over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-cb7ec3e54e204604bbb02da5465f2b1c
出典データセット
uspto-grants-2008_07
特許番号
US07396844B1

関連ノート

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