Hydrochloric Acid → Ethyl 4-(3-cyanophenoxy)-2-butenoate

HRID 747715ノート

反応式

HRID 747715 の反応式
Br[CH2:2]/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6].[OH:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Cl>CN(C)C=O>[C:14]([C:13]1[CH:12]=[C:11]([CH:18]=[CH:17][CH:16]=1)[O:10][CH2:2][CH:3]=[CH:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:15]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 5373944Ethyl (E)-4-bromobut-2-enoate

生成物 1

HCID 54098496Ethyl 4-(3-cyanophenoxy)-2-butenoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1 g (3.9 mmol) of ethyl 4-bromocrotonate, 465 mg (3.9 mmol) of 3-hydroxybenzonitrile, 539 mg (3.9 mmol) of potassium carbonate and 647 mg (3.9 mmol)) of potassium iodide were stirred in N,N-dimethylformamide at room temperature for 3 days. 1 N hydrochloric acid was added to the reaction liquid. After the extraction with ethyl acetate, the extract was washed with 1 N aqueous sodium hydroxide solution and saturated aqueous common salt solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

後処理

  1. extractionAfter the extraction with ethyl acetate
  2. washthe extract was washed with 1 N aqueous sodium hydroxide solution and saturated aqueous common salt solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-1e09a9720de24a10a2518ff677d1b241
出典データセット
uspto-grants-2008_07
特許番号
US07396844B1

反応ノート

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