Potassium Iodide → HCID 68836373、化合物

HRID 747789ノート

反応式

HRID 747789 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13]Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>C[N-]C.C(OCC)(=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:15][C:16]1[CH:23]=[CH:22][CH:21]=[C:18]([C:19]#[N:20])[CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

7

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 54012228tert-Butyl (2R)-2-(chloromethyl)pyrrolidine-1-carboxylate

生成物 1

HCID 68836373HCID 68836373、化合物

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 182180Dimethylazanide溶媒

反応条件

温度
90 °C

実験手順

430 mg (2 mmol) of 1-t-butoxycarbonyl-(2R)-2-chloromethyl pyrrolidine was dissolved in 5 ml of dimethylamide, and 238 mg (2 mmol) of 3-hydroxy benzonitrile, 500 mg (3 mmol) of potassium iodide, and 414 mg (3 mmol) of potassium carbonate were added thereto and stirred at 90° C. for 3 days. The reaction mixture was treated in an ordinary manner with ethyl acetate as the extractant, and the resulting residue was purified by silica gel column chromatography to obtain the title compound.

後処理

  1. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-5319edb120b142f98aa8b1fa45921010
出典データセット
uspto-grants-2008_07
特許番号
US07396844B1

反応ノート

読み込み中…