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Isopropanol → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 5-Amino-4-fluoro-2-methylphenol | HCID 10154098 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 10707048 | — |
| 溶媒 | 2-Pentanol | HCID 22386 | — |
| 生成物 | 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 11617691 | — |
反応手順
A suspension of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.2 g, 0.74 mmol), (prepared as described for the starting material in Example 2), and 2-fluoro-5-hydroxy-4-methylaniline (126 mg 0.89 mmol) in 2-pentanol (2.5 ml) was heated at reflux for 7.5 hours. After cooling, isopropanol was added and the solid was filtered off, washed with isopropanol and ether, and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (yellow solid 196 mg, 64%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087602B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-1d218b8eacb94ccf8ec1aaec2228ab0f |
| 出典メモ | uspto-grants-2006_08 |