Triethylamine → HCID 59750474、化合物
反応式
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].[C:12]([C:14]1[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][N:15]=1)#[N:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[O:10]=[C:1]1[C:2]2[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=2[S:4][C:12]([C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][N:15]=2)=[N:13]1参加物
5
実験手順
A mixture of methyl thiosalicylate (2.1 g, 12.3 mmol), methyl 6-cyanonicotinate (2.0 g, 12.3 mmol), triethylamine (3.0 ml, 21.5 mmol) and toluene (6 ml) was refluxed for 12 hrs as described in Example 1. The precipitated crystals were collected by filtration and recrystallized from diisopropylether-chlorobenzene to give the titled compound (2.1 g, 58%).
後処理
- temperaturewas refluxed for 12 hrs
- filtrationThe precipitated crystals were collected by filtration
- customrecrystallized from diisopropylether-chlorobenzene
出典と根拠
- ORDレコード
- ord-b4ebc2f0fd51440d8ea61ddfc0bc1a48
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07399759B2
反応ノート
読み込み中…