Triethylamine → HCID 68459271、化合物

HRID 748116ノート

反応式

HRID 748116 の反応式
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].C(O[C:16]1[CH:17]=[CH:18][C:19]([C:22]#N)=[N:20][CH:21]=1)(=O)C.[C:24]([O:27]C1C(C#N)=NC=CC=1)(=[O:26])[CH3:25].[CH2:36]([N:38](CC)CC)C>C1(C)C=CC=CC=1>[C:24]([O:27][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([C:36]2[S:4][C:3]3[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=3[C:1](=[O:10])[N:38]=2)=[CH:21][N:20]=1)(=[O:26])[CH3:25]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 21009Benzoic acid, 2-mercapto-, methyl esterHCID 22939311HCID 22939311、化合物HCID 229393796-Cyanopyridin-3-yl acetate

生成物 1

HCID 68459271HCID 68459271、化合物収率 29%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of methyl thiosalicylate (0.58 g, 3.43 mmol), a mixture of 5-acetoxy-2-cyanopyridine and 3-acetoxy-2-cyanopyridine (0.60 g, 3.43 mmol), triethylamine (0.72 ml, 5.15 mmol) and toluene (100 ml) was refluxed for 48 hrs as described in Example 1. The solvent was concentrated under reduced pressure. The residue was recrystallized from ethanol to give the titled compound (0.30 g, 29%) as crystals.

後処理

  1. temperaturewas refluxed for 48 hrs
  2. concentrationThe solvent was concentrated under reduced pressure
  3. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-eb747d87bc62457cb5fc264f7bc4f302
出典データセット
uspto-grants-2008_07
特許番号
US07399759B2

反応ノート

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