化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 2-(4-Phenyl-2-pyridyl)-4H-1,3-benzothiazine-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| 反応物 | 4-Phenyl-2-pyridinecarbonitrile | HCID 87758 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(4-Phenyl-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 59750104 | 53% |
反応手順
A mixture of methyl thiosalicylate (1.00 g, 5.9 mmol), 2-cyano-4-phenylpyridine (1.10 g, 5.9 mmol), triethylamine (1.30 ml, 9.0 mmol) and toluene (2.5 ml) was refluxed for 20 hrs. After cooling, the precipitated crystals were collected by filtration and recrystallized from ethanol to give the titled compound (0.99 g, 53%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07399759B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-6bfd023bf67c4242aeebaa9e89b02d32 |
| 出典メモ | uspto-grants-2008_07 |