tert-Butyl (E)-3-(4-methyl-2-pyridyl)-2-propenoate → tert-Butyl 3-(4-methyl-2-pyridyl)propanoate
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](/[CH:8]=[CH:9]/[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:3]=1>CO.[C].[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:3]=1参加物
4
実験手順
tert-Butyl (E)-3-(4-methyl-2-pyridyl)-2-propenoate (1.9 g, 8.5 mmol) was dissolved in methanol (80 ml), and 10% palladium-carbon (200 mg) was added thereto. The mixture was stirred under hydrogen atmosphere at room temperature for 3 hrs. Palladium-carbon was filtered off, and the filtrate was concentrated to give the titled compound (1.8 g, 90%).
後処理
- filtrationPalladium-carbon was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-435396706b74414ba4dc50a39926d284
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07399759B2
反応ノート
読み込み中…