Triethylamine → 2-(1,3-thiazol-2-yl)-4H-1,3-benzothiazin-4-one
反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]#[N:7].[C:8](OC)(=[O:16])[C:9]1[C:10](=[CH:12][CH:13]=[CH:14][CH:15]=1)[SH:11].C(N(CC)CC)C>C1(C)C=CC=CC=1>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[S:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[C:8](=[O:16])[N:7]=1参加物
5
実験手順
1,3-Thiazole-2-carbonitrile (0.32 g, 2.9 mmol) and methyl thiosalicylate (0.98 g, 5.8 mmol) were dissolved in toluene (4 ml), and triethylamine (2.0 ml, 14.3 mmol) was added thereto. The reaction mixture was refluxed for 2 hrs. After cooling, the precipitates were collected by filtration and recrystallized from diisopropyl ether-ethanol to give the titled compound (0.51 g, 70%) as yellow crystals.
後処理
- temperatureThe reaction mixture was refluxed for 2 hrs
- temperatureAfter cooling
- filtrationthe precipitates were collected by filtration
- customrecrystallized from diisopropyl ether-ethanol
出典と根拠
- ORDレコード
- ord-1a9e12e4546f4710b7ed182e904ca15e
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07399759B2
反応ノート
読み込み中…