4-[(6-Chloropyridin-3-yl)sulfonyl]morpholine → HCID 136342138、化合物
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:17]([C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22]2)#[N:18]>>[OH:28][C:23]1[NH:24][C:25]2[C:21]([C:22]=1[C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)(=[O:10])=[O:9])=[CH:6][N:7]=1)=[CH:20][C:19]([C:17]#[N:18])=[CH:27][CH:26]=2参加物
3
実験手順
The title compound was prepared as described for Example 101 using 4-[(6-chloropyridin-3-yl)sulfonyl]morpholine and 5-cyanooxindole. The reaction mixture was quenched with water and the solvents were evaporated in vacuo. Water was added and the mixture was filtered. The solid material was washed with water, methanol, ethyl acetate and diethyl ether to give the title compound. Yield: 44%: MS (ES) m/z 385 (M++1).
後処理
- customThe title compound was prepared
- customThe reaction mixture was quenched with water
- customthe solvents were evaporated in vacuo
- additionWater was added
- filtration