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Hydrochloric Acid → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 5-Amino-4-fluoro-2-methylphenol | HCID 10154098 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride | HCID 21991058 | — |
| 触媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | 2-Pentanol | HCID 22386 | — |
| 生成物 | 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline | HCID 21991044 | — |
反応手順
A solution of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (132 mg, 0.33 mmol), (prepared as described for the starting material in Example 12), and 2-fluoro-5-hydroxy-4-methylaniline (56 mg, 0.39 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (2.5 ml) containing 7M hydrogen chloride in isopropanol (9drops) was heated at reflux for 30 minutes. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline as an hydrochloride salt (yellow solid, 143 mg, 84%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087602B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-81ac5a108f83462b91d6cd5c4ab875c1 |
| 出典メモ | uspto-grants-2006_08 |