2-Methoxyethanol → 5-isopropoxy-7-(2-methoxyethoxy)quinazolin-4(3H)-one

反応式

F[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[C:4]([O:13][CH:14]([CH3:16])[CH3:15])[CH:3]=1.[CH3:17][O:18][CH2:19][CH2:20][OH:21]>>[CH:14]([O:13][C:4]1[CH:3]=[C:2]([O:21][CH2:20][CH2:19][O:18][CH3:17])[CH:11]=[C:10]2[C:5]=1[C:6](=[O:12])[NH:7][CH:8]=[N:9]2)([CH3:16])[CH3:15]

参加物

反応物 2

HCID 80192-Methoxyethanol

HCID 1362314007-Fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one

生成物 1

HCID 1363519545-isopropoxy-7-(2-methoxyethoxy)quinazolin-4(3H)-one収率 28%

反応条件

温度: 120 °C

実験手順

An analogous reaction to that described in example 137b, but starting with 7-fluoro-5-isopropoxyquinazolin-4(3H)-one (444 mg, 2 mmol) and 2-methoxyethanol (0.32 ml, 4.06 mmol) and heating at 120° C. for 1.5 hours yielded 5-isopropoxy-7-(2-methoxyethoxy)quinazolin-4(3H)-one (155 mg, 28% yield) as a beige solid:

後処理

customAn analogous reaction to

出典と根拠

ORDレコード: ord-f35f3f79f0dd45b1aecbaba59075073f
出典データセット: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07402585B2

反応ノート

読み込み中…