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Methanol → 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy)-7-methoxyquinazolin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy}-7-fluoroquinazolin-4(3H)-one | HCID 136351952 | — |
| 生成物 | 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy)-7-methoxyquinazolin-4(3H)-one | HCID 136351955 | 63.1% |
反応手順
An analogous reaction to that described in example 137b, but starting with 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy}-7-fluoroquinazolin-4(3H)-one (363 mg, 1 mmol) and methanol (162 μl, 4 mmol) at 110° C. for 2 hours yielded 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy}-7-methoxyquinazolin-4(3H)-one (237 mg, 63% yield):
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402585B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-5996ba45bb384c08a9574e4811c5099f |
| 出典メモ | uspto-grants-2008_07 |