Toluene → 2-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one

HRID 749225

反応式

HRID 749225 の反応式
[Br:1]Br.[CH2:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=1)[CH:4]([CH3:6])[CH3:5].C1(C)C=CC=CC=1>C(O)C>[Br:1][CH2:14][C:13]([C:10]1[CH:9]=[CH:8][C:7]([CH2:3][CH:4]([CH3:6])[CH3:5])=[CH:12][CH:11]=1)=[O:15]

参加物

5

反応物 3

HCID 1140TolueneHCID 24408BromineHCID 932144'-Isobutylacetophenone

生成物 1

HCID 136563372-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one収率 57%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
5 °C

実験手順

Bromine (1.25 ml; 25 mmol) is added dropwise to a solution of 4′-isobutylacetophenone (3.52 g; 20 mmol) in 60 ml of ethanol cooled down to approximately 5° C. After stirring the reaction mixture for 30 minutes at this temperature, stirring is continued for one hour at ambient temperature. The reaction medium, to which small portions of toluene are added, is concentrated to dryness. After purification on a silica column (eluent: ethyl-heptane acetate: 5-95), a colourless oil is obtained with a yield of 57%.

後処理

  1. stirringstirring
  2. waitis continued for one hour at ambient temperature
  3. concentrationis concentrated to dryness
  4. customAfter purification on a silica column (eluent: ethyl-heptane acetate: 5-95)
  5. customa colourless oil is obtained with a yield of 57%

出典と根拠

ORDレコード
ord-37cffd1cac174c97ae12e2ea559231b3
出典データセット
uspto-grants-2008_07
特許番号
US07402602B2

関連ノート

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