Pyridinium chloride → 7-Acetyl-4-hydroxybenzo[d]thiazol-2(3H)-one
反応式
[C:1]([C:4]1[C:12]2[S:11][C:10](=[O:13])[NH:9][C:8]=2[C:7]([O:14]C)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].Cl.N1C=CC=CC=1>CN1CCCC1=O.O>[C:1]([C:4]1[C:12]2[S:11][C:10](=[O:13])[NH:9][C:8]=2[C:7]([OH:14])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]参加物
5
実験手順
A mixture of 7-acetyl4-methoxy-1,3-benzothiazol-2(3H)-one (1.2 g), pyridine hydrochloride (2.77 g), in dry 1-methyl-2-pyrrolidone(6 ml), was heated at 190° C. in a microwave reactor for 90 min. The reaction mixture was cooled to room temperature, and diluted with water. The precipitated solid was collected by filtration, washed with water and dried under vacuum at 40° C. to give the title compound (1.07 g). LCMS RT=2.46 min.
後処理
- filtrationThe precipitated solid was collected by filtration
- washwashed with water
- customdried under vacuum at 40° C.
出典と根拠
- ORDレコード
- ord-fe87213bfd7e406bb29aebc33ee06b8e
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07402598B2
反応ノート
読み込み中…