4-Chlorobenzylamine → N-(4-Chlorobenzyl)4-hydroxy-1-methyl-1H-indole-2-carboxamide

反応式

C([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=O)[N:13]2[CH3:18])C1C=CC=CC=1.[Cl:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:19]([C:12]2[N:13]([CH3:18])[C:14]3[C:10]([CH:11]=2)=[C:9]([OH:8])[CH:17]=[CH:16][CH:15]=3)=[O:21])=[CH:25][CH:24]=1

参加物

反応物 2

HCID 660364-Chlorobenzylamine

HCID 47776784-Benzyloxy-1-methyl-1H-indole-2-carboxylic acid

生成物 1

HCID 9926897N-(4-Chlorobenzyl)4-hydroxy-1-methyl-1H-indole-2-carboxamide

実験手順

From 4-benzyloxy-1-methyl-1H-indole-2-carboxylic acid and 4-chlorobenzylamine the title compound was prepared by a method analogous to that described in Example 11. MS ES (M++H)=315 and 317.

出典と根拠

ORDレコード: ord-8a8d2015865b4dbfa3bd8e9b8f58f86f
出典データセット: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07402604B2

反応ノート

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