HCID 22341850、化合物 → HCID 22182264、化合物
反応式
[CH3:1][C:2]1([CH3:13])[CH2:7][C:6](=[O:8])[CH2:5][C:4]([CH2:11][CH3:12])([CH2:9][CH3:10])[NH:3]1>CO>[CH3:13][C:2]1([CH3:1])[CH2:7][CH:6]([OH:8])[CH2:5][C:4]([CH2:9][CH3:10])([CH2:11][CH3:12])[NH:3]1参加物
3
実験手順
To a solution of 15.8 g (0.086 mol) 2,2-dimethyl-6,6diethyl-4-oxopiperidine In 50 ml methanol 2.2 g (0.06 M) sodium borohydride are acided in portions. The temperature is kept below 30° C. After stirring over night methanol is removed under vacuum and the residue is diluted with 20 ml 2N-NaOH. The solution is extracted with ethylacetate. The combined extracts are washed with saturated NaCl solution, dried over MgSO4 and dried under vacuum at 60° C./50 mbar until a constant weight is achieved. 15.8 g (99%) 2,2-dimethyl-6,6-diethyl-4-hydroxypiperidine are obtained as yellowish oil. :
後処理
- customis kept below 30° C
- customis removed under vacuum
- additionthe residue is diluted with 20 ml 2N-NaOH
- extractionThe solution is extracted with ethylacetate
- washThe combined extracts are washed with saturated NaCl solution
- dry with materialdried over MgSO4
- customdried under vacuum at 60° C./50 mbar until a constant weight
出典と根拠
- ORDレコード
- ord-576b029e3eae4e03b2fef7825718fcb1
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07402639B2
反応ノート
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