Ammonium Hydroxide → 2-Amino-1-methylcyclohexan-1-ol
反応式
[CH3:1][C:2]12[O:8][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3]2.[OH-].[NH4+:10]>O>[NH2:10][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1([CH3:1])[OH:8]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 1-methyl-7-oxabicyclo[4.1.0]heptane, 30a, (1.0 g, 7.1 mmol) in water was added ammonium hydroxide (6.0 mL, 154.1 mmol). The mixture was heated to 50° C. for 48 hours. The mixture was diluted with water, extracted with EtOAc and then twice with 20% MeOH/CHCl3. The organic phases were dried (MgSO4), filtered and concentrated in vacuo to provide the desired product, 30b, as an amorphous white solid.
後処理
- extractionextracted with EtOAc
- dry with materialThe organic phases were dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-0e1f6b80027642ee843f29d90f473c6d
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829007B2
反応ノート
読み込み中…