関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Ethyl 2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoate | HCID 69305912 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2,4-Dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoic acid | HCID 68798267 | 89.7% |
反応手順
120 mg (0.31 mmol) of ethyl 2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoate were suspended in 6 ml of an ethanol/2 N sodium hydroxide solution mixture (1:1) and heated at 90° C. for 3 hours. After cooling to room temperature, the pH was adjusted to 2 with 2 N sulfuric acid, and the precipitate was filtered off with suction. 98 mg (88%) of the product were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07402674B2 |
|---|
| 出典データセット | uspto-grants-2008_07 |
|---|
| ORD ID | ord-02347f89e7ff45a3bdaa4e3d85527075 |
|---|
| 出典メモ | uspto-grants-2008_07 |
|---|
