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Sodium hydride → 2-(4-Acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1-[4-(Bromomethyl)phenyl]ethan-1-one | HCID 583785 | — |
| 反応物 | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(4-Acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235039 | 79% |
反応手順
Using 0.3 g of (3,3,3-trifluoropropyl)malononitrile, 3 ml of N,N-dimethylformamide, 0.08 g of sodium hydride (60% in oil), and 0.4 g of 4-acetylbenzyl bromide, and according to the process described in the Production Example 1, there was obtained 0.43 g of 2-(4-acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (6)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402691B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-b959e0b912e0481d9446d9479abfd2e8 |
| 出典メモ | uspto-grants-2008_07 |