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Sodium hydride → 2-(3,3,4,4,4-Pentafluorobutyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1,1,1,2,2-Pentafluoro-4-iodobutane | HCID 110092 | — |
| 反応物 | (4-(Trifluoromethoxy)benzyl)malononitrile | HCID 22235052 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3,3,4,4,4-Pentafluorobutyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile | HCID 22235005 | 31.1% |
反応手順
Using 0.30 g of (4-(trifluoromethoxy)benzyl)malononitrile, 10 ml of N,N-dimethylformamide, 0.06 g of sodium hydride (60% in oil), and 0.38 g of 4-iodo-1,1,1,2,2-pentafluorobutane, and according to the process described in the Production Example 1, there was obtained 0.15 g of 2-(3,3,4,4,4-pentafluorobutyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile (the present compound (10)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402691B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-95c75244584e4461904f1563ff76d33a |
| 出典メモ | uspto-grants-2008_07 |