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Sodium hydride → 2-(3,4-Dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| 反応物 | (3,4-Dichlorobenzyl)malononitrile | HCID 12194483 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3,4-Dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235032 | 45% |
反応手順
Using 2.00 g of (3,4-dichlorobenzyl)malononitrile, 20 ml of N,N-dimethylformamide, 0.36 g of sodium hydride (60% in oil), and 2.37 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.42 g of 2-(3,4-dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (21)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402691B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-844f921be8644fd7a7663208271906d9 |
| 出典メモ | uspto-grants-2008_07 |