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Sodium hydride → HCID 22235051、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1-(Bromomethyl)-4-(propan-2-yl)benzene | HCID 47719 | — |
| 反応物 | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 22235051 | HCID 22235051 | 85% |
反応手順
Using 0.21 g of 4-isopropylbenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.24 g of 2-(4-isopropylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (35)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402691B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-6550b84f378d454888d2a814ca801951 |
| 出典メモ | uspto-grants-2008_07 |