化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 1-Benzyl-3-(3-chloro-phenyl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | Ethyl 4-oxo-1-piperidinecarboxylate | HCID 34767 | — |
| 反応物 | 1-Chloro-3-(2-nitroethenyl)benzene | HCID 2731646 | — |
| 溶媒 | Ethylacetate methanol | HCID 21584119 | — |
| 生成物 | 1-Benzyl-3-(3-chloro-phenyl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine | HCID 59752511 | — |
反応手順
The title compound (0.34 g) was prepared from 3.0 g of 4-oxo-piperidine-1-carboxylic acid ethyl ester, 1.91 mL of benzylamine, and 1.2 g of 1-chloro-3-(2-nitro-vinyl)-benzene as in Example 38. TLC (SiO2, 2% NH3 in MeOH/EtOAc): Rf=0.25. MS (ESI): exact mass calculated for C21H21ClN2, 336.14; found, m/z 337.2 [M+H]+, 339.2 [M+H]+. 1H NMR (500 MHz, CD3OD): 7.36-7.32 (m, 4H), 7.30-7.25 (m, 2H), 7.21-7.16 (m, 4H), 5.15 (s, 2H), 4.41 (s, 2H), 3.53 (t, J=6.3 Hz, 2H), 2.98 (s, 3H), 2.91 (t, J=6.3 Hz, 2H), 2.82-2.70 (m, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402680B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-8818a301c88c423e9ac69a81921c7f6e |
| 出典メモ | uspto-grants-2008_07 |