Hydrochloric Acid → (r)-Piperidin-2-ylmethanol hydrochloride

HRID 749992ノート

反応式

HRID 749992 の反応式
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[CH2:15][OH:16])=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[CH2:15][OH:16]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 6933953tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate

生成物 1

HCID 67247105(r)-Piperidin-2-ylmethanol hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A 4M HCl solution in dioxane (30 mL) was added to (R)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (4.65 g, 21.6 mmol). The mixture was stirred at rt for 3 h. The solvent was removed in vacuo to yield the title product as a hydrochloride salt (3.47 g).

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-25c9d7df0a4f4382ae38b031398e6050
出典データセット
uspto-grants-2008_07
特許番号
US07402684B2

反応ノート

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