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Tetrahydrofuran → 4-(Pyridin-3-yloxy)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 3-(4-Benzyloxy-phenoxy)-pyridine | HCID 68999185 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Pyridin-3-yloxy)phenol | HCID 12940630 | 110.5% |
反応手順
The product from step 1 (130 mg, 0.469 mmol) was added to a vial containing THF (1 ml), EtOH (2.5 ml), 10% Pd/C (110 mg, 0.0469 mmol), charged with H2 and left to stir under H2 atmosphere overnight. The Pd/C was removed by filtering the reaction mixture through celite. The resulting solution was concentrated to give the title compound (97 mg, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402684B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-45d6c08999414c76ab3977698051ce6d |
| 出典メモ | uspto-grants-2008_07 |