Oxirane, 2-propyl- → 1-(4-Methanesulfonylbenzylamino)pentan-2-ol

HRID 750121ノート

反応式

HRID 750121 の反応式
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[O:13]1[CH:15]([CH2:16][CH2:17][CH3:18])[CH2:14]1>CO>[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:10][CH2:14][CH:15]([OH:13])[CH2:16][CH2:17][CH3:18])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

参加物

4

反応物 2

HCID 13853Oxirane, 2-propyl-HCID 574214-Methylsulfonylbenzylamine

生成物 1

HCID 230607521-(4-Methanesulfonylbenzylamino)pentan-2-ol収率 34.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution (50 ml) of 4-methanesulfonylbenzylamine (5.0 g) and 1,2-epoxypentane (2.8 g) in methanol was stirred at room temperature for 96 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1) to give the title compound (2.5 g).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1)

出典と根拠

ORDレコード
ord-2c44bf5e738b40f29830c347e2fc684b
出典データセット
uspto-grants-2008_07
特許番号
US07402595B2

反応ノート

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