1,4-Dioxane hydrochloride → 6-carbamoyl-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

HRID 750257ノート

反応式

HRID 750257 の反応式
O1CCOCC1.Cl.[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([C:39]([O:41]C(C)(C)C)=[O:40])=[CH:35][CH:34]=2)[C:14](=[O:31])[C:15]2[C:20]([C:21]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[CH:19][C:18]([C:28](=[O:30])[NH2:29])=[CH:17][CH:16]=2)=[O:11]>>[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([C:39]([OH:41])=[O:40])=[CH:37][CH:38]=2)[C:14](=[O:31])[C:15]2[C:20]([C:21]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[CH:19][C:18]([C:28](=[O:30])[NH2:29])=[CH:17][CH:16]=2)=[O:11]

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 691570372-(4-tert-butoxycarbonylbenzyl)-6-carbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

生成物 1

HCID 691567496-carbamoyl-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester収率 69%

実験手順

To a 4N-hydrochloric acid dioxane solution (5 ml) was added 2-(4-tert-butoxycarbonylbenzyl)-6-carbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (140 mg), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained crystals were washed with methanol to give the title compound (86 mg).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe obtained crystals were washed with methanol

出典と根拠

ORDレコード
ord-d49cd52b741947b0b91ed9626f7ae955
出典データセット
uspto-grants-2008_07
特許番号
US07402595B2

反応ノート

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