Diisopropylether methanol → 6-chloro-2-(4-methanesulfonylbenzyl)-3-pentanoyl-4-phenyl-2H-isoquinolin-1-one

HRID 750279

反応式

HRID 750279 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=1)[C:6]([CH:24]([OH:29])[CH2:25][CH2:26][CH2:27][CH3:28])=[C:5]2[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.CO.C(OC(C)C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([S:20]([CH3:23])(=[O:21])=[O:22])=[CH:18][CH:19]=1)[C:6]([C:24](=[O:29])[CH2:25][CH2:26][CH2:27][CH3:28])=[C:5]2[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

参加物

3

反応物 2

HCID 21882575Diisopropylether methanolHCID 230605736-chloro-3-(1-hydroxypentyl)-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one

生成物 1

HCID 230608916-chloro-2-(4-methanesulfonylbenzyl)-3-pentanoyl-4-phenyl-2H-isoquinolin-1-one

実験手順

In the same manner as in Example 311, the title compound was synthesized using 6-chloro-3-(1-hydroxypentyl)-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one. Crystals (methanol-diisopropyl ether).

出典と根拠

ORDレコード
ord-8f063e7f513c4a449ea6f96bf9d44f07
出典データセット
uspto-grants-2008_07
特許番号
US07402595B2

関連ノート

読み込み中…