関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride | HCID 21991058 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | 2-Pentanol | HCID 22386 | — |
| 生成物 | 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride | HCID 21991016 | 106.3% |
反応手順
A solution of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (150 mg, 0.36 mmol), (prepared as described for the starting material in Example 12), 4-chloro-2-fluoroaniline (77 mg, 0.53 mmol) in 2-pentanol (4 ml) and 5M isopropanolic hydrogen chloride (1 ml) was heated at 120° C. for 1 hour. The mixture was allowed to cool and isopropanol was added. The resulting precipitate was collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (185 mg, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087602B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-0b7086452ac64a56a87f5db7ea740a99 |
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| 出典メモ | uspto-grants-2006_08 |
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