関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 5-Nitropyrimidin-2-amine | HCID 76490 | — |
| 反応物 | 3-Chloro-4-fluorobenzoic acid | HCID 520989 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-chloro-4-fluoro-N-(5-nitropyrimidin-2-yl)benzamide | HCID 57447263 | 55.1% |
反応手順
To 5-nitropyrimidin-2-amine (1.0 g, 7.1 mmol) in pyridine (10 mL) was added 3-chloro-4-fluorobenzoic acid (1.7 g, 9.7 mmol). The reaction mixture was heated at 100° C. for 4 hrs and allowed to cool to rt. 15 mL H2O was added. A precipitate was collected by filtration and purified by silica gel chromatography, eluting with CH2Cl2 followed by 10% EtOAc/CH2Cl2 to give 1.16 g (55% yield) 1C. RP HPLC ret. t.: 2.22 min. and (M+H)+: 297.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07405213B2 |
|---|
| 出典データセット | uspto-grants-2008_07 |
|---|
| ORD ID | ord-24a01487731d47dc8b9d5a29cafbc925 |
|---|
| 出典メモ | uspto-grants-2008_07 |
|---|
