1-(2-Bromoethoxy)-4-chlorobenzene → (3-{2-[2-(4-Chloro-phenoxy)-ethyl]-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl}-2-methyl-indol-1-yl)-acetic acid

HRID 750651

反応式

HRID 750651 の反応式
C([O:5][C:6](=[O:29])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH:17]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[S:19](=[O:27])(=[O:26])[NH:18]2)=[C:9]1[CH3:28])(C)(C)C.Br[CH2:31][CH2:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=1>>[Cl:40][C:37]1[CH:38]=[CH:39][C:34]([O:33][CH2:32][CH2:31][N:18]2[CH:17]([C:10]3[C:11]4[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=4)[N:8]([CH2:7][C:6]([OH:5])=[O:29])[C:9]=3[CH3:28])[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[S:19]2(=[O:27])=[O:26])=[CH:35][CH:36]=1

参加物

3

反応物 2

HCID 748541-(2-Bromoethoxy)-4-chlorobenzeneHCID 67317115[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-2-methyl-indol-1-yl]-acetic acid tert-butyl ester

生成物 1

HCID 46890180(3-{2-[2-(4-Chloro-phenoxy)-ethyl]-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl}-2-methyl-indol-1-yl)-acetic acid

実験手順

The title compound was prepared by the method described for example 14 using the product from example 3, step c) and 1-(2-bromo-ethoxy)-4-chloro-benzene. MS: ESI (negative): 509 (M−H).

出典と根拠

ORDレコード
ord-eb68c0d101034742a25e86e33a24928c
出典データセット
uspto-grants-2008_07
特許番号
US07405215B2

関連ノート

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