2-Bromoacetamide → 3-Amino-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamide
反応式
Br[CH2:2][C:3]([NH2:5])=[O:4].[SH:6][C:7]1[N:14]=[C:13]([CH3:15])[CH:12]=[C:11]([CH3:16])[C:8]=1[C:9]#[N:10].C[O-].[Na+]>CO>[NH2:10][C:9]1[C:8]2[C:7](=[N:14][C:13]([CH3:15])=[CH:12][C:11]=2[CH3:16])[S:6][C:2]=1[C:3]([NH2:5])=[O:4]参加物
5
実験手順
α-Bromoacetamide (388 mg, 2.81 mmol) was added to a solution of 2-mercapto-4,6-dimethyl-nicotinonitrile (420 mg, 2.56 mmol) in MeOH (25 mL) at room temperature. This was followed by addition of sodium methoxide (1.76 mL, 25% NaOMe in MeOH, 7.7 mmol). The reaction mixture was heated to reflux. Heating at reflux was continued overnight, after which time the reaction mixture was cooled and filtered. The product was dried overnight providing 450 mg (80%) of the title compound, m.p. 238-40° C.
後処理
- temperatureThe reaction mixture was heated to reflux
- temperatureHeating
- temperatureat reflux
- temperatureafter which time the reaction mixture was cooled
- filtrationfiltered
- customThe product was dried overnight
出典と根拠
- ORDレコード
- ord-bfa107bc8670466f97ad0afd21d1f8ef
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07405225B2
反応ノート
読み込み中…