2,4-Dichlorobenzyl alcohol → 2-(2,4-Dichlorobenzyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

HRID 750836

反応式

HRID 750836 の反応式
CS[C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:6]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:5][N:4]=1.[Cl:24][C:25]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:26]=1[CH2:27][OH:28]>>[Cl:24][C:25]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:26]=1[CH2:27][O:28][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:6]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:5][N:4]=1

参加物

3

反応物 2

HCID 156842,4-Dichlorobenzyl alcoholHCID 597539142-Methylthio-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

生成物 1

HCID 597539572-(2,4-Dichlorobenzyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

実験手順

2-Methylthio-5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)pyrimidine from Reference Example 3 was reacted with 2,4-dichlorobenzyl alcohol according to the procedure described in Example 59 to afford 2-(2,4-dichlorobenzyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine (HRf): HPLC/MS: m/e=509 (M++1); Rt=5.07 min; 1H-NMR 400 MHz (CDCl3): δ 5.60 (s, 2H), 7.04 (d, J=9 Hz, 2H), 7.21 (m, 6H), 7.38-7.42 (m, 1H), 7.60 (d, J=9 Hz, 1H), 8.60 (s, 1H).

出典と根拠

ORDレコード
ord-517dd2a1920c4388a6546b4daf4bd0c5
出典データセット
uspto-grants-2008_07
特許番号
US07405221B2

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