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Benzaldehyde → 1-Acetyl-3-tert-butylamino-2-phenyl-imidazo[1,2-a]-pyrimidin-1-ium chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 2-Aminopyrimidine | HCID 7978 | — |
| 反応物 | Tert-Butyl isocyanide | HCID 23577 | — |
| 溶媒 | Perchloric Acid | HCID 24247 | — |
| 生成物 | 1-Acetyl-3-tert-butylamino-2-phenyl-imidazo[1,2-a]-pyrimidin-1-ium chloride | HCID 178418915 | — |
反応手順
Example 3 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) tert.-butylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087607B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-5ebe5abfa2ca49b9841445d97976bc23 |
| 出典メモ | uspto-grants-2006_08 |