Dinitrofluorobenzene → Methyl n-(2,4-dinitrophenyl)glycinate
反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].Cl.[CH3:15][O:16][C:17](=[O:20])[CH2:18][NH2:19].C([O-])([O-])=O.[K+].[K+]>CO>[CH3:15][O:16][C:17](=[O:20])[CH2:18][NH:19][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]参加物
5
反応条件
- 温度
- 60 °C
実験手順
A mixture of 1-fluoro-2,4-dinitrobenzene (1) (15 g, 0.81 mmol), glycine methyl ester hydrochloride (11.5 g, 0.92 mmol), K2CO3 (22.3 g, 0.162 mmol) and methanol (300 mL) was heated at 60° C. for 30 minutes. After cooling in an ice bath, the resulting yellow precipitate was collected by filtration, washed with water and methanol and dried in vacuo. Yield 10.5 g (51%).
後処理
- temperatureAfter cooling in an ice bath
- filtrationthe resulting yellow precipitate was collected by filtration
- washwashed with water and methanol
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-c95a8d16b8e24ff396bc45ab5bd5da43
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07405235B2
反応ノート
読み込み中…