Hydrochloric Acid → methyl (2S,3S)-3-hydroxypyrrolidine-2-carboxylate hydrochloride

反応式

[ClH:1].[OH:2][C@H:3]1[CH2:7][CH2:6][NH:5][C@@H:4]1[C:8]([OH:10])=[O:9].[CH3:11]O>>[ClH:1].[CH3:11][O:9][C:8]([C@@H:4]1[C@@H:3]([OH:2])[CH2:7][CH2:6][NH:5]1)=[O:10]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 440575trans-3-hydroxy-L-proline

生成物 1

HCID 66605223methyl (2S,3S)-3-hydroxypyrrolidine-2-carboxylate hydrochloride

反応条件

温度: 0 °C

実験手順

Hydrogen chloride gas was bubbled through a suspension of trans-3-hydroxy-L-proline (50 g, 0.38 mol) in MeOH (600 mL) cooled to 0° C. for 10 min. The resulting clear solution was stirred at rt for 4 h, then concentrated carefully under reduced pressure (white precipitates formed during the concentration). The resulting white solid was dried under vacuum overnight to afford the title compound (68.26 g) as a white solid.