Hydrochloric Acid → 4-Amino-5,6,7,8-tetrahydronaphthalene-1-carbonitrile, hydrochloride salt
反応式
[C:1]([C:3]1[C:12]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[C:6]([NH:13]C(=O)C)=[CH:5][CH:4]=1)#[N:2].[ClH:17]>CCO>[ClH:17].[NH2:13][C:6]1[C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[C:3]([C:1]#[N:2])=[CH:4][CH:5]=1参加物
4
実験手順
A suspension of 2C (0.40 g, 1.87 mmol) in a mixed solvent of EtOH (2 mL) and conc. HCl (2 mL) was refluxed for 2 h. The resulting solution was allowed to cool to rt and concentrated under reduced pressure. The obtained solid was evaporated with toluene (2×) to yield compound 2D (0.25 g) as a solid.
後処理
- temperaturewas refluxed for 2 h
- concentrationconcentrated under reduced pressure
- customThe obtained solid was evaporated with toluene (2×)
出典と根拠
- ORDレコード
- ord-e4f74e14a85a4e96ae248a078eb03de3
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07405234B2
反応ノート
読み込み中…