Hydrochloric Acid → 1-(Piperidin-4-ylmethyl)-1H-pyrazole-4-carboxamide hydrochloride
反応式
[C:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH:8]=1)(=[O:3])[NH2:2].[ClH:23]>C(O)(C)C>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([CH2:9][N:7]2[CH:8]=[C:4]([C:1]([NH2:2])=[O:3])[CH:5]=[N:6]2)[CH2:11][CH2:12]1参加物
4
実験手順
A suspension of 0.96 g (3.11 mmol) of tert-butyl 4-(4-carbamoylpyrazol-1-ylmethyl)piperidine-1-carboxylate, obtained in stage 13.1., in 25 ml of a 5N solution of hydrochloric acid (124 mmol) in isopropanol is stirred overnight. It is evaporated to dryness and then coevaporated twice with 25 ml of ethyl acetate. The product is resuspended in 25 ml of ethyl acetate. It is filtered, washed twice with 10 ml of ethyl acetate and dried under vacuum in order to obtain 0.91 g (3.23 mmol) of product in the form of a white powder.