化工社化工社 化学情報印刷レポート · 研究参考用
Imidazole → 5-(tert-Butyldimethylsilyloxy)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 5-Hydroxyindole | HCID 16054 | — |
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(tert-Butyldimethylsilyloxy)-1H-indole | HCID 22250817 | 100% |
反応手順
A solution of 5-hydroxy-indole (5 g, 38 mmol), tert-butyldimethylsilyl chloride (6.13 g, 39.4 mmol) and imidazole (5.37 g, 68.1 mmol) in DMF (50 ml) was stirred for 20 h at RT. Diethyl ether was added and the mixture was washed with 1N HCl and water. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give 9.4 g (38 mmol, quant.) 5-(tert-butyl-dimethyl-silanyloxy)-1H-indole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405236B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-3f63406704fd44c7a2243ee88acf4a89 |
| 出典メモ | uspto-grants-2008_07 |